Pets & Animals

Veterinary Biologics

Veterinary biologics are any viruses, serums, toxins and analogous products of natural or synthetic origin, including genetically modified organisms, diagnostics, antitoxins, vaccines, live micro-organisms, killed micro-organisms and the antigenic or immunising component of micro-organisms intended for use in the diagnosis, treatment or prevention of diseases of animals and birds, or for purposes of research in animals or birds. 

AVA regulates the import and transshipment of veterinary biologics, which require valid licences and registration. 

The export of veterinary biologics does not require an AVA export licence.

There are 4 general stages for bringing veterinary biologics into Singapore:

  1. The importer must be licensed to possess veterinary biologics.
  2. Each consignment must come with an AVA import licence. Different import licence requirements apply to different types of veterinary biologics, namely:
    • Vaccines
    • Pathogens
    • Diagnostic Kits
    • Genetically Modified Organisms
  3. Upon arrival in Singapore, each consignment will undergo inspection and sampling.
  4. AVA will audit the licensee’s storage or research premises.



Licence to Possess Veterinary Biologics

To possess and import veterinary biologics (i.e. veterinary vaccines, and pathogens on AVA's select list), you must first obtain a Licence to Possess Veterinary Biologics.

It comes in 2 categories:

  • Licence to Possess Veterinary Biologics (Commercial Purposes)
  • Licence to Possess Veterinary Biologics (Research and Development Purposes)

The Licence is valid for 1 year and should be renewed before it expires.

Below are the steps to apply for the Licence:

Step Description
STEP 1: Download, print and complete the Application for a Licence to Possess Veterinary Biologics.
STEP 2: Submit the completed application form to:

Agri-Food and Veterinary Authority
Agri Establishment Regulation Group
Veterinary Section, Licensing Department
52 Jurong Gateway Road
#09-01
Singapore 608550
Attn: Darren Kong
STEP 3: Pay an annual fee of S$45.
STEP 4: After receiving your application, AVA officers will arrange and conduct an inspection visit to your storage or research premises to evaluate its suitability before the Licence can be issued.

Pay an inspection fee of S$63 per hour or part thereof.
STEP 5: You will be issued the Licence to Possess Veterinary Biologics according to the Conditions for Possession of Biologics (i.e. for Trade or for Research and Development).

For more information and conditions related to the Licence, please read Application Information.

After obtaining the Licence to Possess Veterinary Biologics, you may proceed to apply for an AVA import licence for each of your consignments.

Different application requirements will apply, depending on the type of veterinary biologics you are bringing in. See the relevant sections below for more information.

Import Licence Requirements for Vaccines

Each import consignment of veterinary vaccines must be accompanied by an AVA import licence. In addition:

  • You must have a Licence to Possess Veterinary Biologics before importing vaccines.
  • Veterinary vaccines would need to be evaluated by AVA’s Biologics Evaluation Committee (BEC) and registered with AVA before they can be imported. See AVA's List of Registered Vaccines.  Note that all registered vaccines which have not been imported within 2 years after the date of registration or after the last import will be de-registered.

Apply for AVA Import Licence


You can apply for an AVA import licence for vaccines online via the LicenceOne (AVA e-Licensing) website.

Please note that you will have to log in to the LicenceOne (AVA e-Licensing) website and locate the specific import licensing service.

Type of licence Cost and validity
Licence to Import/Export/Transship Animals, Birds, Eggs and Biologics
  • S$22 (normal service, issuance within 3 working days of submission of complete documents)
  • S$44 (express service, issuance within 2 working days of submission of complete documents)
  • Valid for 30 days from date of issuance
  • Each licence allows you to import or transship 1 consignment

Download the relevant Veterinary Conditions documents listed below for more information on import requirements:


Registration of Vaccines


1. Prepare dossiers for submission

Prepare 2 sets of dossiers according to the format below:

NO. DESCRIPTION
A. Table of Content
B. Product and Manufacturer Information
  1. Name of product and product code number;
  2. Description of product with specimen label, product insert and packaging label;
  3. Composition of product, including history/source of master seed;
  4. Name and address of manufacturer;
  5. Copy of the licence to manufacture the product granted to the manufacturer by the relevant authority of the country of manufacturer;
  6. Other supporting documents, such as:
    • Product registration certificates
    • GMP certificates
    • Certificates of free sale
    • Document from relevant authorities, certifying that: "ingredients of bovine origin used in veterinary biologics must be obtained from countries where there are no cases of BSE"
    • A list of all ingredients of animal origin used in the production of the biological products from the manufacturer. The list should contain information such as name of the material and the country of origin. 
C. Outline of Production (including potency test or immunogenicity test of master seed)
D. Quality Control Tests with Full Description
  1. Sterility test
  2. Purity test
  3. Inactivation test (for inactivated vaccines)
  4. Safety test
  5. Efficacy/Potency test
  6. Specimen copy of the quality control certificate for each batch of the product.
E. Developmental Studies (Summary Reports)
  1. Safety studies
    • Safety of multi-doses in target animals at minimum age of application
    • Inoculation site reaction
    • Transmissibilityof master seed virus (live vaccine) to non-target species
    • Reversion of virulence of vaccine
  2. Inactivation test for activated products
  3. Stability studies under proposed storage conditions
  4. Efficacy studies:
    • Challenge protection in target species
    • Correlation studies (for non-challenge studies)
    • Duration of immunity
    • Compatibility studies with other vaccines, treatment or conditions (where applicable)
  5. Field trials of the final product, especially for safety and efficacy.
  6. Other studies (where applicable):
    • Residue study
    • Occupational health and safety study
    • Environmental risk study
2. Submit dossiers and fee to AVA

Submit your 2 dossiers along with a registration fee of S$210 per vaccine to AVA at:

Agri-Food & Veterinary Authority (Headquarters)
52 Jurong Gateway Road
#14-01
Singapore 608550

As all applications will be presented to the AVA's Biologics Evaluation Committee (BEC) for evaluation, you should submit your applications at least 1 month before the scheduled BEC meeting. The meeting is generally held in the 3rd week of every quarter (i.e. March, June, September and December).

3. Import the registered vaccine

All registered vaccines which have not been imported within 2 years after the date of registration or after the last import will be de-registered.

Import Licence Requirements for Pathogens

Each import consignment of pathogens must be accompanied by an AVA import licence. In addition:

  • You must have a Licence to Possess Veterinary Biologics before importing pathogens.
  • The pathogen you import must be approved by AVA. See AVA’s Select List of Pathogens for a non-exhaustive list of pathogens you can import.

Download the relevant Veterinary Conditions document listed below for more information on import requirements:


Apply for AVA Import Licence


Apply for an AVA import licence for pathogens via TradeNet.

The import licence fee is S$22 per consignment

For pathogens that you have previously imported, the application process generally takes 1 working day.

For pathogens you are importing for the first time, you must submit a risk assessment in the attached format to AVA’s Biologics Evaluation Committee (BEC) for import consideration, via email to:

With approval, you may then proceed to apply for your import licence via TradeNet.



Import Licence Requirements for Samples for Diagnostic Testing

An example of a sample for diagnostic testing is blood serum imported for the Rabies Virus Antibody Indirect ELISA test at AVA’s Animal and Plant Health Centre (APHC).

Below are the steps required to import blood serum into Singapore for rabies testing.

1. Apply for accreditation of veterinarian

Overseas veterinarians submitting blood samples to Singapore for the first time must apply for AVA accreditation. This accreditation is a one-off application.

Below are the steps the overseas veterinarian must follow:

STEP DESCRIPTION
STEP 1: Download and complete AVA's form.
STEP 2: Prepare:
  • the completed form,
  • a copy of your veterinary qualification, and
  • your licence to practise in your country 
STEP 3: Send the 3 prepared documents to AVA via either:
Fax: (65) 6316 1090 or
Email: Chan_Geok_Hua@ava.gov.sg
2. Apply for AVA import licence

Apply online for an AVA import licence via the LicenceOne (AVA e-Licensing) website, once the submitting veterinarian has been accredited by AVA. 

Please note that you will have to log in to the LicenceOne (AVA e-Licensing) website and locate the specific import licensing service.
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Please attach either of the following as supporting documents:

The import licence will be processed and approved in 2 working days.  

Do note that the original completed submission form and veterinary certificate from the submitting veterinarian (issued when the blood sample is taken) must accompany the shipment.

3. Ensure serum and packaging meets requirements

The import should meet the following conditions:

  • The sample is serum, not whole blood.
  • The amount of serum is at least 0.5 ml. 
  • Serum is stored in a screw-capped, leak-proof plastic tube. This sample tube is then wrapped in absorbent material (e.g. paper towel or cotton wool) and placed inside another leak-proof, unbreakable bottle, before being placed in the shipping container.  
  • The sample tube is labelled with the dog/cat's name and microchip number.
  • The sample is shipped together with a cold frozen gel pack (not ice).
  • The sample is shipped together with the original import licence, submission form and veterinary certificate.  
  • The delivery or shipping can be done at ambient temperature.  
  • Refrigeration of the sample during shipping is not required.

4. Inform APHC of Consignment Details

Inform APHC at (65) 6316 5188 of the consignment details once the shipment has been sent out.

5. Inform CAPQ or Tuas Checkpoint for sample inspection

a. For samples arriving as cargo
Inform AVA’s officers at Changi Animal and Plant Quarantine (CAPQ) at (65) 6545 7523 once the shipment has been sent out to alert them on the arrival of the blood sample.  

Importers are also required to send the blood serum to CAPQ for inspection before delivering it to APHC.
b. For hand-carried samples, by air
Contact the AVA officers at CAPQ at (65) 6545 7523 at least 1 day before your arrival to alert them of the arrival of the blood sample.

Upon arrival in Singapore, surrender the blood sample to the 'Lost and Found' counter at the arrival hall. Then, make your way to CAPQ to collect the blood sample and deliver it directly to APHC personally.  

Please note that the laboratory can only accept samples during office hours (8.00 am – 5.00 pm, Monday – Friday). 
c. For hand-carried samples, by road (Tuas Checkpoint only)
Contact the AVA officers at Tuas Checkpoint at (65) 6865 4758 at least 1 day before your arrival to alert them of the arrival of the blood sample.

Upon arrival in Singapore, go to the Cargo Clearance Lane and proceed to the AVA office for inspection. Then, deliver the blood sample directly to APHC personally.  

Please note that the AVA office at Tuas is only open from 8.00 am – 1.00 pm.

If you are delivering the sample personally, you can pay the laboratory fee upon submission of the blood sample if you do not have a GIRO account with AVA.

The test result will be faxed and mailed to you or the submitting veterinarian (as specified) within a week after the receipt of the blood samples.

Animal and Plant Health Centre

Address
Animal and Plant Health Centre
6 Perahu Road (off Lim Chu Kang Road)
Singapore 718827
Contact
Tel: (65) 6316 5188
Fax: (65) 6316 1090

Changi Animal and Plant Quarantine Station

Address Operating Hours
Gate C7, Airport Cargo Road
Changi Airfreight Centre
Changi Animal & Plant Quarantine
Singapore 918104
Monday – Saturday:
8.00am – 1.00pm
2.00pm – 10.30pm
Closed on Sundays and Public Holidays
Contact How to get there*
Tel: (+65) 6545 7523
Fax: (+65) 6545 3023
Bus: 9, 19 and 89 (alight at the 3rd bus stop after Police Pass Office, along Airline Road)
MRT: Bedok (transfer to bus 9), Tampines (transfer to bus 19)

*This travel information is meant for commuters without pets, as animals are not allows on buses and MRT trains.

Download the detailed directions to CAPQ

Tuas Checkpoint

Address Operating Hours
Tuas Operations Command
501 Jalan Ahmad Ibrahim (Block A4)
Singapore 639937
Monday – Saturday: 
8.00am – 1.00pm
Closed on Sundays and Public Holidays
Contact
Tel: (65) 6865 4758
Fax: (65) 6865 4759

Requirements for Genetically Modified Organisms

If you wish to import genetically modified organisms (e.g. viral genomes, micro-organisms) for the purpose of research, you should seek approval from the Genetic Modification Advisory Committee (GMAC).

For more information, please contact the GMAC Secretariat at:

Tel: (65) 6826 6355
Fax: (65) 6478 9581 
E-mail: info@gmac.gov.sg


AVA Inspection, Sampling & Audit of Premises

Inspection & Sampling


Importers of all Veterinary Biologics, except samples for diagnostic testing, are required to book an inspection via the AVA Inspection & Laboratory e-Services before the date of arrival.

Contact AVA Changi Animal & Plant Quarantine (CAPQ) office 5 days before departure of the consignment to notify them of the planned date of departure.

Audit of Premises


To renew your Licence to Possess Veterinary Biologics, your storage or research premises must undergo AVA audit inspection, and your operations must be found satisfactory.

AVA officers may also carry out surprise checks on your premises as and when it is deemed fit.

Transshipment of Veterinary Biologics

An AVA transshipment licence is required for each shipment of veterinary biologics, which includes: 

  • veterinary vaccines, and 
  • pathogens on AVA's select list.

The fee for the transshipment licence is S$22 per consignment

Veterinary Vaccines


Submit your application for a transshipment licence for veterinary vaccines online via the LicenceOne (AVA e-Licensing) website

Please note that you will have to log in to the LicenceOne (AVA e-Licensing) website and locate the "Licence to Import/Export/Transship Animals, Birds, Eggs and Biologics".  

Pathogens on AVA’s select list 


Submit your application for a transshipment licence for pathogens via TradeNet

You will need to provide the appropriate HS codes and product codes. For the lists of products codes, see Product Codes for TradeNet.

Back to Top LAST UPDATED ON Tuesday, January 10, 2017
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